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gene exp pde10a rn00673152 m1  (Thermo Fisher)
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Thermo Fisher gene exp pde10a rn00673152 m1
A Gene Regulatory Network (GRN) from the D1- and D2-MSNs, color and size of nodes relate to centrality in the network, larger circles represent increased centrality, orange edges represent activation, and gray edges inhibition. B Feature plots depicting ZEB1 RNA expression (upper), module scores for ZEB1 suppressed downstream targets (middle), and module scores for ZEB1 activating downstream targets (lower), separately for CocUD (left) and controls (right). C Emapplot summarizing GO overrepresentation results from genes activated (red) and suppressed (turquoise) by ZEB1, PBX3, and ZNF148, the top TFs from regulon scoring. Each circle represents one GO term as a pie chart, indicating the strength of enrichment in the different regulons, represented by color. Edges indicate semantically similar GO terms, with overlapping genes. Circle size indicates the number of genes in the pathway. D Summary of validation analysis in 3-crit model of cocaine use disorder in rats, upper panel was Created in BioRender. Espinola, M. (2025) https://BioRender.com/c99g053 , data are presented as mean values +/- SEM, light gray = controls ( N = 6), gray = 0crit ( N = 6), black = 3crit ( N = 5), differential expression was determined using a Wilcoxon rank sum test, p <t>PDE10A</t> = 0.015, p CACNA1C = 0.026, p KCNIP4 = 0.82, p ZEB1 = 0.82. E RRHO plots showing the concordance between DE results in males and females, rank rank hypergeometric overlap tests were used to identify sex-specific concordance, upper left = upregulated in females and downregulated in males, upper right = upregulated in males and females, lower left = downregulated in males and females, lower right = upregulated in males and downregulated in females. MSNs = medium spiny neurons, GRN = gene regulatory network, CocUD = cocaine use disorder, Ctrl = control, (+) = activating, (-) = suppressing.
Gene Exp Pde10a Rn00673152 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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A Gene Regulatory Network (GRN) from the D1- and D2-MSNs, color and size of nodes relate to centrality in the network, larger circles represent increased centrality, orange edges represent activation, and gray edges inhibition. B Feature plots depicting ZEB1 RNA expression (upper), module scores for ZEB1 suppressed downstream targets (middle), and module scores for ZEB1 activating downstream targets (lower), separately for CocUD (left) and controls (right). C Emapplot summarizing GO overrepresentation results from genes activated (red) and suppressed (turquoise) by ZEB1, PBX3, and ZNF148, the top TFs from regulon scoring. Each circle represents one GO term as a pie chart, indicating the strength of enrichment in the different regulons, represented by color. Edges indicate semantically similar GO terms, with overlapping genes. Circle size indicates the number of genes in the pathway. D Summary of validation analysis in 3-crit model of cocaine use disorder in rats, upper panel was Created in BioRender. Espinola, M. (2025) https://BioRender.com/c99g053 , data are presented as mean values +/- SEM, light gray = controls ( N = 6), gray = 0crit ( N = 6), black = 3crit ( N = 5), differential expression was determined using a Wilcoxon rank sum test, p <t>PDE10A</t> = 0.015, p CACNA1C = 0.026, p KCNIP4 = 0.82, p ZEB1 = 0.82. E RRHO plots showing the concordance between DE results in males and females, rank rank hypergeometric overlap tests were used to identify sex-specific concordance, upper left = upregulated in females and downregulated in males, upper right = upregulated in males and females, lower left = downregulated in males and females, lower right = upregulated in males and downregulated in females. MSNs = medium spiny neurons, GRN = gene regulatory network, CocUD = cocaine use disorder, Ctrl = control, (+) = activating, (-) = suppressing.
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pde10a (myc-ddk-tagged) orf clone  (OriGene)
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A Gene Regulatory Network (GRN) from the D1- and D2-MSNs, color and size of nodes relate to centrality in the network, larger circles represent increased centrality, orange edges represent activation, and gray edges inhibition. B Feature plots depicting ZEB1 RNA expression (upper), module scores for ZEB1 suppressed downstream targets (middle), and module scores for ZEB1 activating downstream targets (lower), separately for CocUD (left) and controls (right). C Emapplot summarizing GO overrepresentation results from genes activated (red) and suppressed (turquoise) by ZEB1, PBX3, and ZNF148, the top TFs from regulon scoring. Each circle represents one GO term as a pie chart, indicating the strength of enrichment in the different regulons, represented by color. Edges indicate semantically similar GO terms, with overlapping genes. Circle size indicates the number of genes in the pathway. D Summary of validation analysis in 3-crit model of cocaine use disorder in rats, upper panel was Created in BioRender. Espinola, M. (2025) https://BioRender.com/c99g053 , data are presented as mean values +/- SEM, light gray = controls ( N = 6), gray = 0crit ( N = 6), black = 3crit ( N = 5), differential expression was determined using a Wilcoxon rank sum test, p <t>PDE10A</t> = 0.015, p CACNA1C = 0.026, p KCNIP4 = 0.82, p ZEB1 = 0.82. E RRHO plots showing the concordance between DE results in males and females, rank rank hypergeometric overlap tests were used to identify sex-specific concordance, upper left = upregulated in females and downregulated in males, upper right = upregulated in males and females, lower left = downregulated in males and females, lower right = upregulated in males and downregulated in females. MSNs = medium spiny neurons, GRN = gene regulatory network, CocUD = cocaine use disorder, Ctrl = control, (+) = activating, (-) = suppressing.
Pde10a (Myc Ddk Tagged) Orf Clone, supplied by OriGene, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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catalytic domain 604 1066  (BPS Bioscience)
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A Gene Regulatory Network (GRN) from the D1- and D2-MSNs, color and size of nodes relate to centrality in the network, larger circles represent increased centrality, orange edges represent activation, and gray edges inhibition. B Feature plots depicting ZEB1 RNA expression (upper), module scores for ZEB1 suppressed downstream targets (middle), and module scores for ZEB1 activating downstream targets (lower), separately for CocUD (left) and controls (right). C Emapplot summarizing GO overrepresentation results from genes activated (red) and suppressed (turquoise) by ZEB1, PBX3, and ZNF148, the top TFs from regulon scoring. Each circle represents one GO term as a pie chart, indicating the strength of enrichment in the different regulons, represented by color. Edges indicate semantically similar GO terms, with overlapping genes. Circle size indicates the number of genes in the pathway. D Summary of validation analysis in 3-crit model of cocaine use disorder in rats, upper panel was Created in BioRender. Espinola, M. (2025) https://BioRender.com/c99g053 , data are presented as mean values +/- SEM, light gray = controls ( N = 6), gray = 0crit ( N = 6), black = 3crit ( N = 5), differential expression was determined using a Wilcoxon rank sum test, p <t>PDE10A</t> = 0.015, p CACNA1C = 0.026, p KCNIP4 = 0.82, p ZEB1 = 0.82. E RRHO plots showing the concordance between DE results in males and females, rank rank hypergeometric overlap tests were used to identify sex-specific concordance, upper left = upregulated in females and downregulated in males, upper right = upregulated in males and females, lower left = downregulated in males and females, lower right = upregulated in males and downregulated in females. MSNs = medium spiny neurons, GRN = gene regulatory network, CocUD = cocaine use disorder, Ctrl = control, (+) = activating, (-) = suppressing.
Catalytic Domain 604 1066, supplied by BPS Bioscience, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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anti pde10a  (Proteintech)
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A Gene Regulatory Network (GRN) from the D1- and D2-MSNs, color and size of nodes relate to centrality in the network, larger circles represent increased centrality, orange edges represent activation, and gray edges inhibition. B Feature plots depicting ZEB1 RNA expression (upper), module scores for ZEB1 suppressed downstream targets (middle), and module scores for ZEB1 activating downstream targets (lower), separately for CocUD (left) and controls (right). C Emapplot summarizing GO overrepresentation results from genes activated (red) and suppressed (turquoise) by ZEB1, PBX3, and ZNF148, the top TFs from regulon scoring. Each circle represents one GO term as a pie chart, indicating the strength of enrichment in the different regulons, represented by color. Edges indicate semantically similar GO terms, with overlapping genes. Circle size indicates the number of genes in the pathway. D Summary of validation analysis in 3-crit model of cocaine use disorder in rats, upper panel was Created in BioRender. Espinola, M. (2025) https://BioRender.com/c99g053 , data are presented as mean values +/- SEM, light gray = controls ( N = 6), gray = 0crit ( N = 6), black = 3crit ( N = 5), differential expression was determined using a Wilcoxon rank sum test, p <t>PDE10A</t> = 0.015, p CACNA1C = 0.026, p KCNIP4 = 0.82, p ZEB1 = 0.82. E RRHO plots showing the concordance between DE results in males and females, rank rank hypergeometric overlap tests were used to identify sex-specific concordance, upper left = upregulated in females and downregulated in males, upper right = upregulated in males and females, lower left = downregulated in males and females, lower right = upregulated in males and downregulated in females. MSNs = medium spiny neurons, GRN = gene regulatory network, CocUD = cocaine use disorder, Ctrl = control, (+) = activating, (-) = suppressing.
Anti Pde10a, supplied by Proteintech, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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A Gene Regulatory Network (GRN) from the D1- and D2-MSNs, color and size of nodes relate to centrality in the network, larger circles represent increased centrality, orange edges represent activation, and gray edges inhibition. B Feature plots depicting ZEB1 RNA expression (upper), module scores for ZEB1 suppressed downstream targets (middle), and module scores for ZEB1 activating downstream targets (lower), separately for CocUD (left) and controls (right). C Emapplot summarizing GO overrepresentation results from genes activated (red) and suppressed (turquoise) by ZEB1, PBX3, and ZNF148, the top TFs from regulon scoring. Each circle represents one GO term as a pie chart, indicating the strength of enrichment in the different regulons, represented by color. Edges indicate semantically similar GO terms, with overlapping genes. Circle size indicates the number of genes in the pathway. D Summary of validation analysis in 3-crit model of cocaine use disorder in rats, upper panel was Created in BioRender. Espinola, M. (2025) https://BioRender.com/c99g053 , data are presented as mean values +/- SEM, light gray = controls ( N = 6), gray = 0crit ( N = 6), black = 3crit ( N = 5), differential expression was determined using a Wilcoxon rank sum test, p <t>PDE10A</t> = 0.015, p CACNA1C = 0.026, p KCNIP4 = 0.82, p ZEB1 = 0.82. E RRHO plots showing the concordance between DE results in males and females, rank rank hypergeometric overlap tests were used to identify sex-specific concordance, upper left = upregulated in females and downregulated in males, upper right = upregulated in males and females, lower left = downregulated in males and females, lower right = upregulated in males and downregulated in females. MSNs = medium spiny neurons, GRN = gene regulatory network, CocUD = cocaine use disorder, Ctrl = control, (+) = activating, (-) = suppressing.
Pde10a Antibodies, supplied by Proteintech, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


A Gene Regulatory Network (GRN) from the D1- and D2-MSNs, color and size of nodes relate to centrality in the network, larger circles represent increased centrality, orange edges represent activation, and gray edges inhibition. B Feature plots depicting ZEB1 RNA expression (upper), module scores for ZEB1 suppressed downstream targets (middle), and module scores for ZEB1 activating downstream targets (lower), separately for CocUD (left) and controls (right). C Emapplot summarizing GO overrepresentation results from genes activated (red) and suppressed (turquoise) by ZEB1, PBX3, and ZNF148, the top TFs from regulon scoring. Each circle represents one GO term as a pie chart, indicating the strength of enrichment in the different regulons, represented by color. Edges indicate semantically similar GO terms, with overlapping genes. Circle size indicates the number of genes in the pathway. D Summary of validation analysis in 3-crit model of cocaine use disorder in rats, upper panel was Created in BioRender. Espinola, M. (2025) https://BioRender.com/c99g053 , data are presented as mean values +/- SEM, light gray = controls ( N = 6), gray = 0crit ( N = 6), black = 3crit ( N = 5), differential expression was determined using a Wilcoxon rank sum test, p PDE10A = 0.015, p CACNA1C = 0.026, p KCNIP4 = 0.82, p ZEB1 = 0.82. E RRHO plots showing the concordance between DE results in males and females, rank rank hypergeometric overlap tests were used to identify sex-specific concordance, upper left = upregulated in females and downregulated in males, upper right = upregulated in males and females, lower left = downregulated in males and females, lower right = upregulated in males and downregulated in females. MSNs = medium spiny neurons, GRN = gene regulatory network, CocUD = cocaine use disorder, Ctrl = control, (+) = activating, (-) = suppressing.

Journal: Nature Communications

Article Title: Cell type-specific multi-omics analysis of cocaine use disorder in the human caudate nucleus

doi: 10.1038/s41467-025-57339-y

Figure Lengend Snippet: A Gene Regulatory Network (GRN) from the D1- and D2-MSNs, color and size of nodes relate to centrality in the network, larger circles represent increased centrality, orange edges represent activation, and gray edges inhibition. B Feature plots depicting ZEB1 RNA expression (upper), module scores for ZEB1 suppressed downstream targets (middle), and module scores for ZEB1 activating downstream targets (lower), separately for CocUD (left) and controls (right). C Emapplot summarizing GO overrepresentation results from genes activated (red) and suppressed (turquoise) by ZEB1, PBX3, and ZNF148, the top TFs from regulon scoring. Each circle represents one GO term as a pie chart, indicating the strength of enrichment in the different regulons, represented by color. Edges indicate semantically similar GO terms, with overlapping genes. Circle size indicates the number of genes in the pathway. D Summary of validation analysis in 3-crit model of cocaine use disorder in rats, upper panel was Created in BioRender. Espinola, M. (2025) https://BioRender.com/c99g053 , data are presented as mean values +/- SEM, light gray = controls ( N = 6), gray = 0crit ( N = 6), black = 3crit ( N = 5), differential expression was determined using a Wilcoxon rank sum test, p PDE10A = 0.015, p CACNA1C = 0.026, p KCNIP4 = 0.82, p ZEB1 = 0.82. E RRHO plots showing the concordance between DE results in males and females, rank rank hypergeometric overlap tests were used to identify sex-specific concordance, upper left = upregulated in females and downregulated in males, upper right = upregulated in males and females, lower left = downregulated in males and females, lower right = upregulated in males and downregulated in females. MSNs = medium spiny neurons, GRN = gene regulatory network, CocUD = cocaine use disorder, Ctrl = control, (+) = activating, (-) = suppressing.

Article Snippet: Specific TaqManTM Gene Expression Assays were used to detect the genes of interest: PDE10A (Rn00673152_m1), KCNIP4 (Rn00710466_m1), CACNA1C (Rn00709287_m1), and ZEB1 (Rn01538408_m1).

Techniques: Activation Assay, Inhibition, RNA Expression, Biomarker Discovery, Quantitative Proteomics, Control